Cancer Panel Genetic Predisposition Test

Cancer affects us all. We all know someone who has it, survived it, or sadly, was taken too soon by it. Although some cancers develop due to a combination of chance and our environment, up to 10% of all cancers are linked to a relative, or an inherited gene mutation.

A cancer that is caused by a genetic mutation is called a hereditary cancer, and is most commonly passed on from parents to their children. Hereditary cancers often develop earlier than other forms of cancer, and can sometimes be more aggressive than the same type of cancer in a non-hereditary patient.

 

There is only one way to determine if you carry a cancer related gene, and that is with a screening test. Our Cancer Panel Genetic Predisposition Test can provide peace of mind for people concerned about hereditary cancers including Breast, Ovaria, Prostate, Colorectal (Bowel) and skin cancers. This screening test analyses of 130 different genes associated with a number of hereditary cancers, testing for the most common mutations.

 

 Our unique DNA are made up of small molecules, called nucleotides, which carry instructions for how the different proteins in our body should be put together. If there is a difference in the sequence of nucleotides, this can result in changes to the way proteins function. This is called a mutation, and results in the creation of a new genetic trait, or occasionally, a disorder or a disease.  


Below is a list of the heredity cancers tested for in this test.

 

IP,AKT1,ALK,ANTXR1,APC,ASCC1,ATM,ATR,AXIN2,BAP1,BARD1,BLM,BMPR1A,BRCA1,BRCA2,BRIP1,
BUB1,BUB1B,CACNA1D,CBL,CDC73,CDH1,CDK4,CDKN1B,CDKN2A,CHEK2,CTHRC1,CYLD,DDB2,DICER,EGFR,ELAC2,EPCAM,ERCC2,ERCC3,ERCC4,ERCC5,EXT1,EXT2,FANCA,FANCB,FANCC,FANCD2,FANCE,
FANCF,FANCG,FANCI,FANCL,FANCM,FH,FLCN,GPC3,HNF1A,HNF1B,HOXB13,KDR,KIT,KLLN,LIG4,MAX,
MEN1,MET,MITF,MLH1,MLH3,MRE11A,MSH2,MSH6,MSR1,MTAP,MUTYH,MYH8,NBN,NCOA4,NF1,
NF2,NTRK1,PALB2,PALLD,PDGFRB,PHOX2B,PIK3CA,PMS2,POLD1,POLE,POLH,PPM1D,PRF1,PRKAR1A,PRSS1,PTCH1,PTCH2,PTEN,PTPN11,RAD50,RAD51C,RAD51D,RB1,RECQL4,RET,RHBDF2,RNASEL,
RNF168,RSPO1,RUNX1,SBDS,SDHA,SDHAF2,SDHB,SDHC,SDHD,SETBP1,SH2D1A,SLX4,SMAD4,SMARCB1,SMARCE1,SPINK1,SPRED1,STK11,SUFU,TERT,TGFBR1,TMEM127,TP53,TSC1,TSC2,VHL, WAS, WRN,WT1,XPA,XPC,XRCC2.

 

This is a simple test that only requires a blood draw, from which your DNA is extracted and analysed using Next Generation Sequencing Technology. The blood draw must be performed by a qualified sample collector, and will incur an additional cost. It is important to note that this test also requires you to attend a genetic counselling session with a qualified professional, who will also receive your results, to then discuss at a time that suits you both.