Pharmacogenomics
It may be a big word, but Pharmacogenomics is simply the way in which genes play a part in how an individual responds to drugs. With many illnesses, we can spend many months trying to find the right drug, or the right combination of drugs to provide the most successful treatment. This trial and error method wastes valuable time and money, and can have a detrimental effect on one’s overall health.
The way in which medications are metabolised is largely dependent on your unique genetic makeup. Some medications are used by the body quickly, and others are slower to react. This can change how successful a medication is for you and your needs.
This test analyses the DNA from a simple blood sample, and will reveal your genetic likelihood to respond to a number of given medications, as well as your risk of having an adverse reaction to these medications.
The Pharmacogenomics PGx test can assist medical practitioners in administering the correct type of medication and dosage for you, assisting in getting you feeling better, sooner, with minimal side effects.
There are 12 PGx panels available, and the initial cost is for 2 tests. Additional tests can be purchased by arrangement.
Anaesthesiology
Discover your ability to metabolise the following medications:
Anaesthetic, Muscle Relaxants.
Endocrinology
Discover your ability to metabolise the following medications:
Contraceptives, Androgens, Anti-androgens, Glucocorticoid, Thyroid.
Infectology
Discover your ability to metabolise the following medications:
Antibiotics, Antimalarial, Anthelmintic, Antifungal, Antiretroviral, Antiviral.
Internal Medicine
Discover your ability to metabolise the following medications: Drugs prescribed for modulation of Respiratory Function, Antiemetic, drugs prescribed for treatment of Peptic Ulcer and/or Gastro-oesophageal and reflux disease, drugs prescribed for treatment of Functional Gastrointestinal Disorders and Obesity, Diabetes medications, Migraine medications, Antihistamines, Abortifacient, drugs prescribed for treatment of Hyperparathyroidism, Dermatology.
Modulation of Cardiovascular Function
Discover your ability to metabolise the following medications: Antiarrhythmic, Antihypertensive I, Antihypertensive II, Cardiac Stimulants, Vasodilators, Angina medications, Drugs prescribed for the treatment of Dyslipidaemia, Anticoagulants, Anti-platelet Drugs. In addition, this panel also assesses SNP’s of importance for treatment using statins, as well as SNP’s for importance of Venous Thromboembolism risk.
Neurology
Discover your ability to metabolise the following medications: Drugs prescribed for treatment of ADHD and related drugs, Treatment of Epilepsy, Anxiolytic, Hypnotic, Sedative, Anticonvulsant, Muscle Relaxants, Alzheimer’s and Parkinson’s Related Drugs. In addition this panel also assesses a range of SNP’s of Importance for different Medical Condition and personality, as well as SNP’s of Importance for hypersensitivity reactions.
Oncology, Haematology
Discover your ability to metabolise the following medications: Antineoplastic I, Antineoplastic II, Antineoplastic Targeted Therapy I, Antineoplastic Targeted Therapy II.
Organ Transplantation
Discover your ability to metabolise the following medications:
Immunosuppressive, Immunomodulatory.
Pain Management
Discover your ability to metabolise the following medications: Anti-inflammatory, analgesic, antipyretic, opioids, anti-rheumatic, drugs prescribed for the treatment of gout. It will also assess a range of additional SNP’s (single nucleotide polymorphisms; the most common type of genetic variation occurring in humans) of Importance for pain management.
Psychiatry
Discover your ability to metabolise the following medications: Antidepressant I, Antidepressant II, as well as additional SNPs of Importance for Treatment Using Antidepressants, additional SNPs of Importance for the Treatment of Depression and Psychosis, and the Treatment of Alcohol and Tobacco Use Disorders, Typical Antipsychotic, Atypical Antipsychotic, additional SNP’s of Importance for treatment that includes the use of antipsychotics and for the treatment of autism.
Recreational Drugs
Discover your ability to metabolise the following medications:
Alcohol, Barbiturates, Benzodiazepines, Cannabinoids, Synthetic Cannabis, Dissociative Drugs, Tobacco, as well as additional SNP’s of Importance for Recreational Drugs.
Urology
Discover your ability to metabolise the following medications:
Drugs prescribed for the treatment of Incontinence, Erectile Dysfunction and Benign Prostatic Hypertrophy.
Ordering and Results
We require that you consult a genetic counsellor both prior to, and after your test. Total DNA Services will requests a referral letter from your GP or genetic counsellor. A genetic counsellor can assist in deciphering your results, so that you get the best and most accurate information relating to your individual test.
When you order the Pharmacogenomics PGx Test, Total DNA Services will send you the appropriate referral forms for your genetic counsellor or doctor to complete. We then send your sample collection kit directly to one of our affiliated pathology centres. We will arrange your appointment for sample collection.
After analysis, your results will be sent to your genetic counsellor or doctor, at which time they will discuss them thoroughly with you.
You will receive your result within 2-3 weeks.